Overview: In a study published in Aging Clinical and Experimental Research, researchers found a potential correlation between mean levels of Vitamin D and the number of cases and rates of mortality caused by COVID-19.
Article Citation: Ilie, P.C., Stefanescu, S. & Smith, L. The Role Of Vitamin D In The Prevention Of Coronavirus Disease 2019 Infection And Mortality. Aging Clin Exp Res(2020). https://doi.org/10.1007/s40520-020-01570-8
Abstract Link: View Here
Study Methodology: Systematic Review
Human or Animal Participants: Human
Who Does This Research Impact: This study can provide guidance about the potential protective factor of Vitamin D in treating individuals infected with COVID-19 and is particularly important for individuals who are presently deficient in Vitamin D.
How to Use this Info:
Are Results of this Study Consistent With Other Related Studies: A deficiency in Vitamin D is a major public health concern throughout the world in all age groups, but is of particular concern for those over 70 years of age. Vitamin D levels deteriorate with age from decreased sun exposure and cutaneous synthesis.
Previous studies have examined the role Vitamin D supplementation plays in protecting against acute respiratory tract infections. A 2017 meta-analysis revealed that patients who were Vitamin D deficient, often those over 70 years old, experienced the greatest benefit. Additional studies have demonstrated that Vitamin D plays numerous roles in the immune system response to infection, including impairing macrophages from maturing and producing antigens.
Limitations of Study: The major limitation of this study is that Vitamin D levels are not currently available for COVID-19 patients. Researchers relied on previously established links between Vitamin D and the immune response to respiratory tract infections. Based on these links, the researchers in this study were able to establish a correlation between Vitamin D levels and the rate of COVID-19 deaths; however, further research is needed to account for other factors through direct measurement of Vitamin D levels among COVID-19 patients.
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